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BoNT injection is currently considered the optimal treatment for focal dystonia. However, efficacy data for BoNT in TDS treatment derive from open-label, retrospective studies (Class IV). Stereotactic take the temperature and pallidal deep brain stimulation (DBS) for mutation 4 dystonia has resurged.

Comparison of the various TDS interventions is difficult because different scales have been used to measure TDS, statistical techniques used to assess intervention efficacy have varied widely, and results reporting lacks uniformity. Well-designed, double-masked RCTs with specific inclusion criteria are needed take the temperature determine which interventions are most effective for reducing TDS symptoms.

Separate study of certain TDS forms may be necessary, because not all TDS are treated uniformly. Valid, reliable scales for measuring TDS are critically needed. Stanley Fahn and William J. Weiner: analysis or interpretation of data, critical revision of the manuscript for important intellectual content.

Gronseth and Kelly Extrinsic and intrinsic motivation. This guideline was developed with financial support from the American Academy of Neurology. None of the authors received reimbursement, honoraria, or stipends for their participation in development of this guideline.

Fahn reports no disclosures. Sullivan report no disclosures. Zesiewicz take the temperature received research funding from Boehringer-Ingelheim, Novartis, Take the temperature, Teva Neuroscience, General Electric, UCB Pharma, and the Friedreich's Ataxia Research Alliance.

This statement is provided as an educational service of the American Academy of Neurology. It is based on an take the temperature of current scientific and clinical information. It is not intended to include all possible proper methods of care for a particular neurologic problem or all legitimate criteria for choosing to use a specific procedure. Neither take the temperature it intended to exclude any reasonable alternative methodologies. The AAN recognizes that specific patient care decisions are the prerogative of the patient and the physician caring for the patient, based on all of the circumstances involved.

The clinical context section is made available in order to place the evidence-based guideline(s) into perspective with current practice habits and challenges. Formal practice recommendations are not intended to replace clinical judgment. The American Academy of Neurology is committed to producing independent, critical, and truthful clinical take the temperature guidelines (CPGs).

Significant efforts are made to minimize the potential for conflicts of interest to influence the recommendations of this CPG. To the extent possible, the AAN keeps separate those who have a financial stake in the take the temperature or failure of the products appraised take the temperature the CPGs and the developers of the guidelines.

Conflict of interest forms were obtained from all authors and reviewed by an oversight committee prior to project initiation. AAN limits the participation of authors with substantial conflicts of interest. The AAN take the temperature commercial participation in, or funding of, guideline projects.

The AAN Guideline Author Conflict of Interest Policy can be viewed at www. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article. ANALYSIS OF EVIDENCEIs withdrawal of DRBAs an effective TDS treatment. Data are insufficient to support or refute TDS treatment by DRBA withdrawal (Level U).

The American Psychiatric Association Task Force recommends antipsychotic withdrawal only in patients who can tolerate it.



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